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RINGED SİDEROBLAST


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Medicine and Hematology Glossary

RINGED SİDEROBLAST

(Medicine and Hematology Glossary) :
Normal kemik iliğinde demir boyası ile eritroblast sitoplazmasında demir granülleri görülebilir. Bu hücreler sideroblast olarak bilinir. Granül sayısı 5'den azdır. Sayı 5'den fazlaysa patolojiktir. Demir granülleri çekirdek etrafını bir halka gibi sarıyor ve bunlar çekirdek çevresinin 1/3'nden fazla bir alan işgal ediyorsa ringed sideroblast olarak adlandırılır. Ringed sideroblast myelodisplastik sendromların (MDS) tüm formlarında görülebilir. Tipik olarak da "refractory anemia with ringed sideroblasts" (RARS) olarak bilinen bir alt grupta bulunurlar. MDS'nin RARS formunda ringed sideroblast sayısı %15'den fazladır.
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