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REPTİLAZ ZAMANI


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Medicine and Hematology Glossary

REPTİLAZ ZAMANI

(Medicine and Hematology Glossary) :
Bazı yılan zehirleri trombin gibi aktivite göstererek fibrinojeni fibrine çevirir. Bu etki trombinden farklı olarak heparinden etkilenmez, dolayısıyla heparin tedavisi altındaki hastalarda trombin zamanı yerine kullanılabilir. Test için Bothrops atrox zehiri kullanılır (laboratruvar kullanımları için ticari olarak satılmaktadır). Sitratlı plazmaya eklenir ve fibrin oluşumuna kadar geçecek süre hesaplanır. Normalde 15-18 saniyedir. Reptilaz zamanı uzaması: 1. Hipofibrinojenemi (1g/L'den az ise), 2. Disfibrinojenemi, 3. Fibrin yıkım ürünleri bulunması, 4. Paraproteinler bulunması
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