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RAPPAPORT SINIFLAMASI


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Medicine and Hematology Glossary

RAPPAPORT SINIFLAMASI

(Medicine and Hematology Glossary) :
Hodgkin-dışı lenfomalar için uzun yıllar en yaygın kullanılan sınıflamadır. Lenfomaları hücre morfolojisi ve lenf bezindeki infiltrasyon paterninin nodüler veya diffüz oluşuna göre sınıflandırır. Eksiklerine karşın anlaşılması kolaydır ve klinikle korelasyonu iyidir. Rappaport sınıflamasında tümör hücreleri büyüklük ve morfoloji olarak normal lenfositlere benziyorsa iyi diferansiye lenfositik, lenfositlere benzeyen ancak nükleusu angule ve irregüler ise az diferansiye lenfositik, normal lenfositin 2-3 misli büyüklükte ve bol sitoplazmalı ise makrofajlara benzetilerek histiyositik, eğer lenfosit ya da histiyositlere benzetilememiş ise undiferansiye olarak adlandırılır. Nodüler pattern gösterenler ve hücreleri iyi farklılaşmış olanlarda prognoz daha iyi kabul edilir. Rappaport sınıflamasında histiyosit olarak adlandırılan hücrelerin aslında histiyosit olmadıkları, büyük lenfoid hücreler oldukları ileriki yıllarda anlaşılmıştır.
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