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LENFOBLASTİK LENFOMA


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Medicine and Hematology Glossary

LENFOBLASTİK LENFOMA

(Medicine and Hematology Glossary) :
Erişkinlerde tüm Hodgkin-dışı lenfomalarının ancak %5'i bu grupta yer alır. Çocuklardaki lenfomaların ise %40'ını oluşturur. Erkeklerde sıktır. Klinik seyir ve hücrelerin yüzey işaretleri yönünden T hücreli akut lenfoblastik lösemiye benzer. Çoğunluğu T lenfosit kökenlidir. TdT, CD7 ve CD3 antijenleri pozitifdir. CD2 ve CD5 pozitiflikleri değişkendir. Doku kesitleri ALL gibidir. Büyük mediastinal kitleler oluşturması önemli özelliğidir ve timik orijini düşündürür. Mitoz hızı yüksektir, çok agressif seyirlidir. Tanı konulduğunda olguların çoğu ileri evrededir. Tedavi edilmeyen olgularda genellikle akut lösemiyle sonuçlanarak hastanın kaybına yol açar. SSS tutulumu sıktır. Köken aldığı hücre prekürsör T lenfositlerdir.
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