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HAM ASİT HEMOLİZ TESTİ


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Medicine and Hematology Glossary

HAM ASİT HEMOLİZ TESTİ

(Medicine and Hematology Glossary) :
1937 yılında Thomas Hale Ham tarafından tanımlanmıştır. Paroksismal noktürnal hemoglobinüri (PNH) tanısında kullanılır. Testin prensibi PNH hastasının eritrositlerinin HCl asit ile titre edilerek Ph'sı 6.8'e inidirilmiş (asidifiye edilmiş) normal serum ile karşılaştığında lizis göstermesine dayanır. Hücre lizisi kompleman aktivasyonuna bağımlıdır ve kompleman inaktive edilirse lizis olmaz. Konjenital diseritropoetik anemilerde de Ham testi müspet çıkabilir. Hücre lizisi kompleman aktivasyonuna bağımlıdır ve kompleman inaktive edilirse lizis olmaz. Spesifik bir testtir, ancak sensitivitesi azdır.
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