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CYCLOSPORIN


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Medicine and Hematology Glossary

CYCLOSPORIN

(Medicine and Hematology Glossary) :
İmmünsüpressif bir ilaç. Günümüzde tranplantasyon rejeksiyonları için yaygın kullanılmaktadır. İmmünolojik kökenli hastalıkların tedavilerinde de kullanılır. B lenfositler, granülositler ve makrofajlara zarar vermeksizin selektif olarak yardımcı T lenfositler üzerine etki yapar. IL-2 sentezini azaltır. IL-2 reseptör ekspresyonunu da azalttığı düşünlmektedir. Nefrotoksik ve hepatotoksiktir. Hipertansiyon yapabilir. Oral ya da IV yoldan verilebilir. Doz: 5-20 mg/kg/gün.
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