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RH (RHESUS) SİSTEMİ


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Medicine and Hematology Glossary

RH (RHESUS) SİSTEMİ

(Medicine and Hematology Glossary) :
Kan transfüzyonları bakımından ABO sisteminden sonra ikinci önemli sistem Rh sistemidir. Çok karışık bir sistemdir. Eritrositlerin yüzeyindeki C, c, D, E, ve e antijenlerine göre düzenlenmiştir. Bu antijenlerden İmmünojenitesi en güçlü olanı D olduğu için rutin Rh tayininde anti-D antiserumları kullanılır ve kişide D antijeni varsa Rh(+), yoksa Rh(-) olarak isimlendirilir. Gelişmiş kan bankaları Rh (-) kararı verirken sadece D antijeninin negatif oluşu ile yetinmemekte ve bu kanları C ve E için de inceleyip (-) olduklarını saptadıktan sonra Rh (-) sonucu vermektedir. D antijeninden sonra immünojenitesi en yüksek olanlar c ve E'dir. Rh(-) bir kişiye yapılacak platelet transfüzyonları sırasında eğer donör Rh (+) ise, ürün içinde karışmış olarak bulunabilecek az miktardaki eritrositler alıcıyı immünize edebilecektir. Böyle bir durumda alıcı kadınsa ve ileride bebek yapması söz konusu olabilecekse Rh Ig yaparak immünizasyona karşı önlem alınmalıdır.
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