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HOWELL-JOLEY


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Medicine and Hematology Glossary

HOWELL-JOLEY

(Medicine and Hematology Glossary) :
Yuvarlak kırmızı renkli, küçük, sitoplazmik inklüzyonlardır. Eritrosit prekürsörlerinde çekirdek materyalinin kopmalarıyla oluşmuşlardır. Normalde dalak tarafından dolaşımdan uzaklaştırıldıkları için sağlıklı kişilerde görülmezler. Splenektomi sonrasında veya diğer nedenlere bağlı hiposplenism durumlarında saptanırlar. Megaloblastik ve diseritropoetik anemilerde Howell-Jolly oluşumu artar, bu hastalarda hiposplenism durumu varsa periferik kanda görülebilirler. Howell-Jolly cisimciklerinin görülmesi için özel boya gerekmez, giemsa ile boyanmış yaymalarda görülürler.
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